the direction say to apply the lacquer to each nail daily. will the ciclopirox have a local or system effect? why?Ciclopirox (Penlac) is an antifungal used to treat onychomycosis,a type of nail fungus.?
After you apply the lacquer to your skin, the ciclopirox will penetrate through the epidermis (outer layer of your skin, made up in most areas of the body of 5 layers) into the dermis.
Even under occlusion (which increases absorption), less than 1.5% of the ciclopirox is absorbed into the systemic circulation. Ciclopirox has a short half-life (1.7 hours), so no systemic accumulation occurs and therefore no systemic effect will occur.
To answer your question in a more succinct manner - there is only a small amount of absorption into the systemic circulation (%26lt;1.5%) due to the protective function of the skin and the properties of the drug.
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